Degradation of glutathione inAspergillus nidulans— Short communication
نویسندگان
چکیده
منابع مشابه
Nonenzymatic, self-elimination degradation mechanism of glutathione.
In the present in vitro studies, evidence is provided showing that glutathione (GSH) can undergo spontaneous, nonenzymatic auto-degradation. The initial cleavage of the Glu-Cys bond involves nucleophilic attack of the N-terminal amino group of GSH at the gamma-carbonyl side chain, followed by an unusual cleavage of the Cys-Gly amide bond that is complete within 3-5 weeks in the physiological pH...
متن کاملShort Communication Aromatic Substitution Reaction of 2-Chloropyridines Catalyzed by Microsomal Glutathione S-Transferase
We investigated the substitution reaction of a series of 2-chloropyridine derivatives catalyzed by rat liver microsomal glutathione S-transferase 1. Various 2-chloropyridine derivatives were metabolized to the corresponding substituted glutathione conjugates via displacement of chlorine atom with glutathione. The reaction was affected by the electron-withdrawing strength and position of the sub...
متن کاملShort Communication Glutathione Transferase P1 Interacts Strongly with the Inner Leaflet of the Plasma Membrane
GSH transferases (GSTs) are a superfamily of proteins best known for detoxifying harmful electrophilic compounds by catalyzing their conjugation with GSH. GSTP1 is the most prevalent and widely distributed GST in human tissues, helping to detoxify a diverse array of carcinogens and drugs. In contrast with its protective role, overexpression of GSTP1 in a variety of malignancies is associated wi...
متن کاملShort Communication BIOFLAVONOID STIMULATION OF GLUTATHIONE TRANSPORT BY THE 190-kDa MULTIDRUG RESISTANCE PROTEIN 1 (MRP1)
In tumor cells, the human multidrug resistance protein 1 (MRP1), confers resistance to a broad spectrum of anticancer agents. MRP1 is also expressed in many normal tissues where it acts as an ATP-dependent transporter of organic anions. Reduced glutathione (GSH) is transported by MRP1 with very low affinity, and certain MRP1 substrates are transported in association with this tripeptide. Previo...
متن کاملShort Communication BIOFLAVONOID STIMULATION OF GLUTATHIONE TRANSPORT BY THE 190-kDa MULTIDRUG RESISTANCE PROTEIN 1 (MRP1)
In tumor cells, the human multidrug resistance protein 1 (MRP1), confers resistance to a broad spectrum of anticancer agents. MRP1 is also expressed in many normal tissues where it acts as an ATP-dependent transporter of organic anions. Reduced glutathione (GSH) is transported by MRP1 with very low affinity, and certain MRP1 substrates are transported in association with this tripeptide. Previo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Biologica Hungarica
سال: 2015
ISSN: 0236-5383,1588-256X
DOI: 10.1556/018.66.2015.2.10